The AU-3S JSM Group is designed to complement work done by national committees by improving signal detection and management by combining safety data and its assessment across countries. The AU-3S JSM Group further promotes collaboration between countries, creates a forum for technical support from reference regulatory authorities to African regulatory authorities, and provides an opportunity to strengthen capabilities of AU-3S JSM Group members. The AU-3S JSM Group is currently limited to only reviewing COVID-19 vaccine related safety data, but plans to expand to additional products as the programme scales in the future.